The vertebrate adaptive immune systems (Agnatha and Gnathostomata) use sets of T and B lymphocyte lineages that somaticallygenerate highly diverse repertoires of Ag-specific receptors and Abs. In Gnathostomata, cytokine networks regulate the activationof lymphoid and myeloid cells, whereas little is known about these components in Agnathans. Most gnathostome cytokines arefour-helix […]
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Glioblastoma (GBM) harbors a highly immunosuppressive tumor microenvironment (TME) which influences glioma growth. Major efforts have been undertaken to describe the TME on a single-cell level. However, human data on regional differences within the TME remain scarce. Here, we performed high-depth single-cell RNA sequencing (scRNAseq) on paired biopsies from the […]
Deniz Kaymak is this year’s recipient of prestigious Swiss National Science Foundation MD-PhD award in Hutter’s lab (June 2022). Way to go, Deniz!